Screen 4.3× more gene targets on the same budget.
Arrayed, batch-matched knockout libraries: 20+ genes in a single cell line, built in one run and ready to expand and screen.
Send us your gene list. We’ll scope the library.
- knockout editing efficiency target with XDel multi-guide designs, verified by Sanger genotyping QC + ICE
- >90%
- from gene list to assay-ready cells
- 4–5 weeks
- gene knockouts arrayed in a single cell line + controls (immortalized, iPSC, primary fibroblast)
- 20–360+
- lower cost per edit than single pools
- Save 70-80%
The problem
The bigger the screen, the bigger the trade-offs.
High costs, long timelines, and run-to-run variability often mean researchers test fewer genes.
Build it yourself
Guide titrations, transfection tuning and QC for every target eat researcher hours. Efficiency varies across plates and genes, which means noisy assays and costly reruns.
Order pools one at a time
At about $2,700 per pool, a 30-gene panel costs $81,000. Separate production runs add batch effects, and pools arrive on different schedules.
Outsource custom cell lines
Custom pricing puts 20–360+ target panels out of reach. Turnaround often runs to months, and QC metrics, guide chemistry and cell yields differ by supplier.
There’s a better way to run a 20+ gene panel.
How it works
From gene list to assay-ready rack in 4–5 weeks.
We handle guide design, editing and QC. Your team starts at the assay.
Send your gene list
Tell us your genes and cell line. We scope the library and send you a quote.
We design and edit in one batch
EditCo handles guide design, XDel multi-guide transfection and editing. Every pool is made in the same run, on the same line, on the same day.
Every pool is verified
Sanger + ICE sequencing confirms knockout efficiency. Mycoplasma, viability and passage number are checked for each pool.
Expand and screen
Receive a 96-tube arrayed rack with ~20,000 cells per tube and 2 vials per pool. Expand in-house and run your assay.
Why ECL
More edits, cleaner data, less hands-on work.
More edits for your budget
Pay for the edit, not the cell mass. Put the savings into more targets.
- 30-edit ECL is $17,700 vs. $18,900 for 7 individual KO pools: 4.3× the targets
- 30-gene ECL is $17,700 vs. $81,000 in individual KO pools: 78% lower for ECL
- 20-gene immortalized screen with Q4 promo is $11,440 vs. $54,000 in individual KO pools
One batch, every gene, data you can actually compare
ECL edits your entire 20+ gene panel in one run, on one line, on one day. Identical conditions mean clean gene-to-gene comparisons, with no run-to-run variability and virtually eliminating reruns.
- 2 replicates per gene and 5 controls per rack give built-in reference wells
- >90% KO with multi-guide fragment deletion
- Same XDel multi-guide design as our pools
Ready to screen, with QC
The rack arrives assay-ready with the QC report. No guide titrations, no transfection tuning, no troubleshooting.
- 96-tube arrayed rack, ~20,000 cells per tube, 2 vials per pool
- Sanger + ICE, mycoplasma, viability and passage number per pool
- 4–5 week turnaround
The budget math
Same budget, up to 4.3× more targets.
Tiered per-edit pricing cuts cost per edit by 70% - 80% compared with individual KO pools at about $2,700 each.
30-gene ECL for $17,700
7 individual pools for $18,900
30-gene ECL
30 individual KO pools
Per-edit pricing
- ECL List Price
- $715 → $550
- Launch Promo: Save 20% (Ends Dec 15)
- $572 → $440
Price per edit falls as your library grows.
Get pricing for your panelWhat arrives in every rack
Assay-ready, documented and comparable.
- Format
- 96-tube arrayed rack
- Library size
- 20 to 360+ gene knockouts in one cell line
- Cells
- ~20,000 cells per tube, 2 vials per pool
- Built-in controls
- 2 replicate pools per gene, 5 control wells per rack
- Editing
- XDel multi-guide fragment deletion, >90% KO
- QC report
- Sanger + ICE, mycoplasma, viability and passage number per pool
- Turnaround
- 4–5 weeks
ECL Customer Example
Using EditCo's ECLs, Dr. Krogan accelerated his research into viral disease biology, contributing to six scientific publications in just one year and helping advance a research program to an active Phase III study in just 9 months.
Nevan Krogan, PhDDirector Quantitative Biosciences Institute, UCSFPublished in Science: Gordon et al. Comparative host-coronavirus prot interaction networks reveal pan-viral disease mechanisms. Read the paper
Questions, answered.
- How many genes can I include?
- ECL libraries cover 20 to 360+ gene knockouts in a single cell line, arrayed in 96-tube racks.
- Which cell lines are supported?
- Immortalized, iPSC, and Primary Fibroblasts across supported cell lines and customer-supplied lines. For other cell types, please reach out to your EditCo Sales Representative.
- What is the ECL guarantee?
- EditCo guarantees that, for each plate (batch) of the Engineered Cell Library, at least 70% of pools will be successfully analyzed by Sanger sequencing and ICE. Of the successfully analyzed pools, at least 70% will have an indel frequency of ≥50%.
- How is knockout efficiency verified?
- Every pool is analyzed by Sanger sequencing and ICE. Libraries are built with XDel multi-guide fragment deletion for >90% knockout efficiency, and each pool ships with mycoplasma, viability and passage number QC.
- What exactly do I receive?
- 2 replicates of 96-tube arrayed racks with ~20,000 cells per tube and 5 controls per rack. Each gene is made as 2 replicate pools, each rack includes 5 control wells, and a full QC report comes with it.
- How long does it take?
- Ships in as little as 4–5 weeks from gene list submission to assay-ready cells.
- Can I carry my hits into validation?
- Yes. ECL uses the same XDel multi-guide design as EditCo’s knockout pools and clones, so hits move into validation without switching guide designs or re-optimizing transfections.
- What does it cost?
- Per-edit pricing is tiered: $715 down to $550, falling as library size grows. Send your gene list for an exact quote.
- I don't have 20 genes of interest. Can I still use the ECL?
- If you don't have 20 genes of interest, consider adding phenotypic controls and other genes from the pathway to complete your ECL and give your results full biological context.
Send us your gene list. We’ll scope your library.
Screen more targets, with cleaner data, inside the budget and timeline you already have.
- Share your genes, cell line and timeline
- We scope the library and send your quote
- Your rack ships with its QC report in 4–5 weeks