Product OverviewOrder KitContact Sales
CRISPR Reagents

Gene Knockout Kits (GKO Kits)

SETDB1 Gene Knockout Kit (Human)

Configure your kit

Bulk Upload

$409.00

Need a quote? Add to cart and download one instantly at checkout — to reference on a purchase order, submit for budget approval, or keep for your records. No need to contact sales.

The same high performing XDel multi-guide design that powers our knockout cells delivered in as fast as 2 days for human genes. Knock out any human or mouse protein-coding gene with >80% efficiency.

Learn More About Gene Knockout KitsDownload Quick Start GuideExplore More Data in XDel Application Note

Gene

SETDB1

ENSG00000143379
Summary
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]
Gene Ontology
Molecular Function14
Biological Process4
Cellular Component5
Popular knockout targets

Data

Gene Knockout Kits Provide Superior Editing Efficiency in iPSC, Immortalized, and Primary Cells and Consistent Protein Depletion Using the XDel Design

Figure 1. A) On-target editing efficiency of XDel multiple guide design (MGKO) (pink bars) vs their 3 respective single-guide RNAs (blue bars) across 7 endogenous target loci transfected in two immortalized (IMM) and two iPSC cell lines. Each transfection was performed in triplicate and data were analyzed via NGS by EditCo’s proprietary software analysis. B) Western blot analyses for all 5 knockout target genes indicate a complete depletion of proteins across the 3 specified time points (days 7, 14, and 21) relative to the negative controls. Knockout cell pools for the target genes were generated by nucleofecting U2OS cells with multi-guide sgRNA and Cas9 (as RNPs). A negative control pool was also transfected for each target using non-targeting sgRNA.

Explore More Data

About XDel Technology

XDel is a cutting-edge CRISPR knockout technology designed to remove the guesswork from gene editing. By leveraging an innovative guide RNA design strategy, XDel delivers highly efficient, consistent, and reproducible gene knockouts—empowering researchers to accelerate their discoveries with confidence.