Product OverviewOrder KitContact Sales
CRISPR Reagents

Gene Knockout Kits (GKO Kits)

RPL38 Gene Knockout Kit (Human)

Configure your kit

Bulk Upload

$409.00

Need a quote? Add to cart and download one instantly at checkout — to reference on a purchase order, submit for budget approval, or keep for your records. No need to contact sales.

The same high performing XDel multi-guide design that powers our knockout cells delivered in as fast as 2 days for human genes. Knock out any human or mouse protein-coding gene with >80% efficiency.

Learn More About Gene Knockout KitsDownload Quick Start GuideExplore More Data in XDel Application Note

Gene

RPL38

ENSG00000172809
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008]
Gene Ontology
Molecular Function3
Biological Process5
Cellular Component10
Popular knockout targets

Data

Gene Knockout Kits Provide Superior Editing Efficiency in iPSC, Immortalized, and Primary Cells and Consistent Protein Depletion Using the XDel Design

Figure 1. A) On-target editing efficiency of XDel multiple guide design (MGKO) (pink bars) vs their 3 respective single-guide RNAs (blue bars) across 7 endogenous target loci transfected in two immortalized (IMM) and two iPSC cell lines. Each transfection was performed in triplicate and data were analyzed via NGS by EditCo’s proprietary software analysis. B) Western blot analyses for all 5 knockout target genes indicate a complete depletion of proteins across the 3 specified time points (days 7, 14, and 21) relative to the negative controls. Knockout cell pools for the target genes were generated by nucleofecting U2OS cells with multi-guide sgRNA and Cas9 (as RNPs). A negative control pool was also transfected for each target using non-targeting sgRNA.

Explore More Data

About XDel Technology

XDel is a cutting-edge CRISPR knockout technology designed to remove the guesswork from gene editing. By leveraging an innovative guide RNA design strategy, XDel delivers highly efficient, consistent, and reproducible gene knockouts—empowering researchers to accelerate their discoveries with confidence.