Scaling Cell Culture with Argo Automation: How EditCo Delivers High-Throughput Precision

Delivering high-quality, precisely edited cells requires more than just cutting-edge CRISPR technology—it begins with a strong foundation in cell culture.

Meet Argo: The Backbone of EditCo’s Automated Cell Culture

Named after the legendary ship that carried Jason and the Argonauts, Argo represents our modern-day vessel for scientific exploration. Housed in a sterile enclosure, Argo is the backbone of our cell culture operations, built for high-throughput expansion, refeeding, and imaging of both immortalized and induced pluripotent stem (iPS) cells.

Figure 1. Photo of the Argo workcell.

The Challenge of Scaling Cell Culture

Every scientist working with cells understands that cell culture requires careful monitoring, regular feeding, and strict environmental control to ensure optimal growth. Managing a few plates manually is feasible, but as demand increases, so do the challenges. Variability, human error, and workflow bottlenecks make scaling up difficult.

Argo rises to the challenge as a fully integrated automation platform that not only takes on the labor-intensive aspects of cell culture but also ensures consistency, precision, and scalability. With the power of software and automation, Argo manages thousands of different samples across hundreds of unique cell lines for weeks at a time, with the ability to scale and grow as customer needs evolve.

Argo seamlessly integrates robotics, liquid handlers, imaging systems, and data pipelines to maintain clonal cell cultures with minimal human intervention. Figure 2 provides an overview of Argo’s closed-loop workflow, illustrating the continuous cycle of incubation, routine refeeding, cell expansion, imaging, and data integration that make up the automated cell culture process. Each component plays a critical role in ensuring consistent, high-throughput cell culture:

Figure 2. Components of automated cell culture performed by Argo.

• Storage & Plate Handling: Plates are housed in temperature-controlled incubators, each capable of holding hundreds of plates at a time. Specialized robotics move plates throughout the workcell as needed.
• Liquid Handling: Automated plate washers, media dispensers, and liquid handlers ensure precise and reliable cell refeeding and expansion workflows.
• Imaging & Quality Control: Argo captures tens of thousands of images daily, providing real-time feedback on cell growth and confluence.
• Data Integration: All images and growth metrics are automatically uploaded to our Laboratory Information Management System (LIMS), ensuring seamless tracking and quality assessment.

This integrated approach reduces human touch time dramatically, allowing scientists to focus on high-value tasks while Argo handles the routine workflows.

Efficiency at Scale

One of the clearest advantages of automation is its ability to scale without increasing manual effort. In our imaging workflow, Argo processes 10 plates with virtually no human touch time. In contrast, the manual imaging workflow requires repeated hands-on steps for every plate, limiting scientists’ capacity to work efficiently on other tasks (Figure 3).

Figure 3. Manual versus automated imaging timeline for 10 plates.

As the number of plates increases, the efficiency gap grows exponentially. For example, imaging 100 plates manually demands over 25 hours of human labor. With Argo, the same task requires less than an hour of human involvement—while the system autonomously executes the bulk of the workflow (Figure 4).

Figure 4. Human touch time required for imaging workflows at increasing plate volumes.

Consistency, Quality, and Traceability

Beyond saving time, automation makes cell culture more reliable and easier to scale. By utilizing standardized, programmable protocols, automated systems eliminate the day-to-day differences that come with manual handling. This leads to higher quality and more consistent results, which is especially important when managing hundreds of cell lines or scaling up production.

As summarized in Figure 5, the shift from traditional to automated workflows affects nearly every dimension of the process: from reduced error rates and increased throughput, to full digital traceability.

Figure 5. High-level comparison of traditional versus automated cell culture workflows.

Argo is Software-Powered

While Argo’s robotic systems handle the physical workload, its intelligence lies in the software powering every step. Each plate is guided by a custom build manifest generated by our LIMS, ensuring that:

• Each sample receives the correct media, timing, and incubation conditions.
• Workflows are dynamically adjusted based on real-time data.
• Process efficiency is continuously improved using data-driven insights.

This modular software architecture allows EditCo to rapidly scale and adapt to new cell lines, experimental goals, and customer specficiations–without disrupting operations.

AI-Powered Image Analysis for QC

Imaging is critical for cell culture quality control, but manual review of thousands of daily images isn’t scalable. To meet this challenge, we utilize AI-powered computer vision to:

• Detect confluence and clonal growth trends across thousands of wells.
• Flag anomalies such as irregular cell growth or differentiation.
• Deliver actionable insights directly to scientists for decision-making.

Figure 6 highlights how our AI models monitor cell growth and death over time. By analyzing changes in well images over several days, Argo distinguishes between successful clonal expansion and declining cell health. This automation enables a small team to maintain rigorous QC across massive volumes of cell culture work.

Figure 6. Time-lapse images showing AI-tracked clonal cell growth in a well.

Unique Build Manifests for Every Customer Plate

Every customer order at EditCo is unique–different cell types, experimental goals, and QC needs. To ensure that each order is processed exactly as required, our software generates a unique build manifest for every plate. These manifests define:

• Liquid handling protocols tailored to cell type.
• Imaging and incubation schedules optimized for each experiment.
• Real-time adjustments based on growth trends.

Figure 7. Argo’s software architecture.

This system diagram above provides a high-level view of Argo’s data flow. The architecture supports continuous, two-way communication between all software layers, enabling real-time feedback from instruments to inform upstream logic. This tightly integrated pipeline ensures traceability, adaptability, and high-throughput quality control at scale.

Data-Driven Optimization

Automation at EditCo isn’t just about scale—it’s about continuous improvement. Every step in Argo’s pipeline is instrumented to capture real-time data, which we use to:

• Optimize reagent usage, reducing costs without compromising quality.
• Identify growth trends, improving experimental reproducibility.
• Continuously refine workflows, ensuring we stay ahead of industry demands.

With around-the-clock monitoring and data analysis, Argo provides our team with an unprecedented level of process oversight, allowing us to detect issues before they impact results.

A Smarter Way to Scale Cell Culture: Built for the Future of Cell Editing

Gene editing is advancing rapidly, and at EditCo, we believe automation is key to unlocking its full potential.  With Argo’s AI-powered imaging and fully integrated software ecosystem, we are setting a new standard for high-throughput, reproducible, and efficient cell culture.

Contact EditCo today to learn how Argo can accelerate your research and take your CRISPR workflows to the next level.